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January 4, 2024Open Access

In mixed plaques, calcified portions increased (p < 0.0001) and non-calcified plaque volume decreased (p = 0.0209), while PCAT attenuation decreased after one year in the LAD (p = 0.0142).

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Why the study?

PCAT attenuation on CTA is a credible indicator of coronary inflammation in CAD, but the long-term effects of high-dose statins on PCAT attenuation and plaque distribution required evaluation.

Does long-term high-dose statin treatment reduce pericoronary inflammation and improve plaque distribution in patients with typical chest pain and documented atheromatous plaque?

Population

52 patients with typical chest pain, low-to-intermediate likelihood of CAD, and documented atheromatous plaque

Comparison

Long-term high-dose statin treatment

Design

Prospective observational study

Follow-up

One year

Authors

BMB MatyasIBImre BenedekNRNóra Raț

Discussion

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Overview

High-dose statin therapy is associated with reduced pericoronary inflammation and favorable changes in plaque morphology on coronary CTA after one year.

Structured PICO

Does long-term high-dose statin treatment reduce pericoronary inflammation and improve plaque distribution in patients with typical chest pain and documented atheromatous plaque?

P
Population
52 patients with typical chest pain, a low-to-intermediate likelihood of CAD, and documented atheromatous plaque through CCT, mean age 60.43
I
Intervention
Long-term high-dose statin treatment
O
Outcome
Pericoronary adipose tissue (PCAT) attenuation at coronary lesion sites and changes in plaque distributionsurrogate

High-dose statin therapy is associated with reduced pericoronary inflammation and favorable changes in plaque morphology on coronary CTA after one year.

Cite This Study

Matyas et al. (2024) studied this question.

synapsesocial.com/papers/6a905d5d6419f6799027a5dchttps://doi.org/10.20944/preprints202401.0374.v1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Assessing the Impact of Long-Term High-Dose Statin Treatment on Pericoronary Inflammation and Plaque Distribution—A Comprehensive Coronary CTA Follow-Up Study2024 · 27 citations
  2. 2Assessing the impact of long-term high-dose statin treatment on perivascular inflammation and plaque distribution - a comprehensive coronary CTA follow-up study2024
  3. 3Longitudinal Effects of Lipid-Lowering Treatment on High-Risk Plaque Features and Pericoronary Adipose Tissue Attenuation Using Serial Coronary Computed Tomography2025 · 1 citations
  4. 4Reduction of perivascular inflammation following long-term statin treatment - a coronary CT follow-up study using Fat Attenuation Index2023 · 4 citations
  5. 5Effect of coronary calcium-informed statin therapy on peri-coronary adipose tissue attenuation in intermediate-risk patients: post-hoc analysis of the CAUGHT-CAD randomised-controlled trial2025 · 1 citations