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May 13, 2025Scientific ReportsOpen Access

High PCAT attenuation was independently associated with an increased risk of MACE (HR 2.41, 95% CI 1.02-5.69, p=0.045) and a higher prevalence of vulnerable plaque characteristics on OCT.

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Why the study?

The relationship between CCTA-derived peri-coronary adipose tissue attenuation, OCT-assessed plaque characterization, and clinical outcomes remained inadequately explored.

Does high PCAT attenuation predict vulnerable plaque characteristics and major adverse cardiac events in patients with coronary artery disease?

Population

111 CAD patients undergoing sequential CCTA, CAG, and OCT

Comparison

High-PCAT attenuation vs low-PCAT attenuation

Design

Retrospective cohort study

Follow-up

Median 504 days

Authors

CYCaifeng YangCDChancui DengJXJie Xia

Discussion

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Member takes

Overview

Should not yet change CAD risk stratification; hypothesis-generating for PCAT attenuation pending prospective validation.

Structured PICO

Does high PCAT attenuation predict vulnerable plaque characteristics and major adverse cardiac events in patients with coronary artery disease?

P
Population
111 patients with coronary artery disease (acute coronary syndromes and stable angina pectoris) who underwent a sequential diagnostic workup comprising CCTA, coronary angiography (CAG), and OCT. Mean age 58.56, 70.3% male. Excluded patients with prior revascularization.
I
Intervention
High peri-coronary adipose tissue (PCAT) attenuation (≥ -70.1 HU) assessed by CCTA
C
Comparator
Low peri-coronary adipose tissue (PCAT) attenuation (< -70.1 HU) assessed by CCTA
O
Outcome
Major adverse cardiac events (MACE), a composite of all-cause mortality, recurrent nonfatal myocardial infarction, ischemia-driven revascularization, recurrent angina, and heart failure recurrence post-discharge at median 504 days follow-upcomposite

Elevated peri-coronary adipose tissue attenuation on CCTA is significantly associated with OCT-detected vulnerable plaque characteristics and an increased risk of major adverse cardiac events in patients with coronary artery disease.

Cite This Study

Yang et al. (2025) studied this question.

synapsesocial.com/papers/6a0908bebee8d5ab8a92dbb4https://doi.org/10.1038/s41598-025-00023-4
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Coronary Inflammation and Plaque Vulnerability: A Coronary Computed Tomography and Optical Coherence Tomography Study2023 · 46 citations
  2. 2Patient-Level Pericoronary Adipose Tissue Mean Attenuation: Associations with Plaque Characteristics2024 · 1 citations
  3. 3Pericoronary fat attenuation in stenotic and vulnerable coronary artery plaques: Implications for coronary artery disease and associated conditions2025 · 3 citations
  4. 4“Pericoronary adipose tissue attenuation as a marker of global coronary inflammation rather than lesion-specific risk”2026
  5. 5Pericoronary adipose tissue computed tomography attenuation distinguishes different stages of coronary artery disease: a cross-sectional study2020 · 131 citations