Key result
Higher pericoronary adipose tissue attenuation links to greater non-calcified but lower calcified plaque burden.
Why the study?
Pericoronary adipose tissue attenuation is emerging as an inflammation marker, but its relationship with plaque characteristics, plaque burden, and coronary calcification required evaluation.
Is pericoronary adipose tissue attenuation associated with specific plaque characteristics in patients with suspected chronic coronary syndrome?
Population
466 patients with suspected chronic coronary syndrome undergoing clinically indicated CCTA
Comparison
PCATa compared across plaque types, compositional plaque volumes, and coronary calcification scores
Design
Observational study
Authors
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May mark perivascular inflammation in vulnerable plaque; hypothesis-generating for risk stratification in suspected CCS.
Observational (n=466)
Is pericoronary adipose tissue attenuation associated with specific plaque characteristics in patients with suspected chronic coronary syndrome?
Effect estimate: β = 7.0 for non-calcified plaque burden, β = -3.5 for calcified plaque burden
p-value: p=<0.05
Higher pericoronary adipose tissue attenuation is associated with non-calcified plaque burden, suggesting a link between perivascular inflammation and vulnerable plaque characteristics.
Overgaard et al. (2024) conducted an observational in suspected chronic coronary syndrome (n=466). Pericoronary adipose tissue attenuation (PCATa) was evaluated on plaque characteristics, including plaque type, burden, and coronary calcification (β = 7.0 for non-calcified plaque burden, β = -3.5 for calcified plaque burden, p=<0.05). Pericoronary adipose tissue attenuation was positively associated with non-calcified plaque burden (β = 7.0) and negatively correlated with calcified plaque burden (β = -3.5) (p<0.05).
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