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April 8, 2026International Journal of ObesityOpen Access

The effect of weight-loss surgery in patients with obesity on adipose tissue mesenchymal stem cells versus circulating endothelial progenitor cells

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Authors

NYNing YangMSMina Al SaeediAXAiling Xue

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Overview

This research demonstrates the effects of weight-loss surgery on stem cells in obesity, indicating potential for improved healing.

Key Points

  • The research aims to investigate the effects of obesity on stem cells and whether weight-loss surgery can reverse these effects.
  • Collected abdominal adipose tissue and blood samples from 8 patients with obesity pre- and post-weight-loss surgery.
  • Assessed mitochondrial function in mesenchymal stem cells and quantified circulating endothelial progenitor cells.
  • Compared findings to healthy control samples.
  • Patients with obesity had higher body mass index compared to healthy controls and post-surgery.
  • Obese patients showed increased mitochondrial oxidative stress in mesenchymal stem cells but improved after surgery.
  • Elevated percentages of circulating endothelial progenitor cells were noted in obese patients but showed no significant reduction post-surgery.

Cite This Study

Yang et al. (2026) studied this question.

synapsesocial.com/papers/69d5f0bb74eaea4b11a7a26chttps://doi.org/10.1038/s41366-026-02057-8
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