What does this research mean for the field?

Folate-conjugated PLGA-PEG nanoparticles encapsulating 9-bromo-noscapine significantly enhance the drug's anticancer efficacy, cellular uptake, and in vivo bioavailability compared to the free drug in breast cancer models. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To evaluate the design and efficacy of PLGA-PEG-FA nanoparticles for targeted delivery of noscapinoids in breast cancer treatment.

April 8, 2026Drug Development Research

Design and Development of PLGA‐PEG‐FA Nanoparticles Encapsulating Noscapinoids for Receptor‐Mediated Breast Cancer Treatment

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Authors

NBNamita Bhoi PNP. NaikSambalpur University

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Implication

Research shows improved anticancer efficacy in breast cancer using folate-conjugated nanocarriers, suggesting enhanced treatment options.

Key Points

To evaluate the design and efficacy of PLGA-PEG-FA nanoparticles for targeted delivery of noscapinoids in breast cancer treatment.
Synthesis and characterization of folate-conjugated PLGA-PEG nanoparticles
In vitro cytotoxicity tests compared to free drugs
Western blot analysis for apoptosis-related protein expression
In vivo pharmacokinetic studies for bioavailability assessment
Enhanced anticancer efficacy observed with nano-formulated drugs
Increased cellular uptake and mitochondrial membrane potential
Higher levels of reactive oxygen species (ROS) in treated cells
Improved bioavailability and prolonged circulation of the nano-encapsulated drug

Cite This Study

Bhoi et al. (2026) studied this question.

synapsesocial.com/papers/69d5f0ee74eaea4b11a7a55d https://doi.org/10.1002/ddr.70278

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Design and Development of PLGA‐PEG‐FA Nanoparticles Encapsulating Noscapinoids for Receptor‐Mediated Breast Cancer Treatment

Discussion

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Implication

Key Points

Cite This Study

Design and Development of PLGA‐PEG‐FA Nanoparticles Encapsulating Noscapinoids for Receptor‐Mediated Breast Cancer Treatment

Discussion

Member takes

Implication

Key Points

Cite This Study

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