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October 1, 2025Medical Journal of BabylonOpen Access

Synthesis of SLN Nanoparticles Containing Naringenin Decorated with Folate-Conjugated Chitosan to Evaluate its Anticancer Effects

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Authors

WAWurood Al-KaritiARAli B. RoomiHAHamed Amiri

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Overview

This study investigates the toxic effects of solid lipid nanoparticles with naringenin in breast cancer, indicating potential for targeted therapy.

Key Points

  • Chitosan-folate-coated solid lipid nanoparticles showed higher toxicity in breast cancer cells compared to free drugs.
  • Nanoparticles decreased angiogenesis, reflected in reduced blood vessel length and embryo weight.
  • Evaluation revealed enhanced apoptosis in cancer cells linked to increased reactive oxygen species and P53 expression.
  • Nanoparticles exhibited bacterial inhibitory effects, presenting additional therapeutic potential against infections.

Cite This Study

Al-Kariti et al. (2025) studied this question.

synapsesocial.com/papers/68dd9537fe798ba2fc499581https://doi.org/10.4103/mjbl.mjbl_677_24
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