What question did this study set out to answer?

To investigate the effectiveness of metagenomic next-generation sequencing (mNGS) for diagnosing severe cat bite infections with negative aerobic cultures.

April 8, 2026BMC Infectious DiseasesOpen Access

Metagenomic next-generation sequencing (mNGS) for severe cat bite infections with negative aerobic culture: a single-center retrospective study in a rabies vaccination center

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To investigate the effectiveness of metagenomic next-generation sequencing (mNGS) for diagnosing severe cat bite infections with negative aerobic cultures.
Retrospective analysis of clinical data from 17 patients with cat bite infections at a rabies vaccination center.
Patients underwent emergency debridement and empirical antibiotic therapy.
mNGS was utilized for pathogen detection in severe cases with no improvement after conventional treatment.
All 17 patients had negative aerobic cultures, with deep puncture wounds observed.
mNGS identified multiple anaerobic pathogens in one severe case, primarily Bacteroides pyogenes (67.5%).
Post-mNGS adjustments to antibiotic regimens led to effective infection control in all severe patients.

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Implication

This retrospective study evaluates mNGS for identifying pathogens in severe cat bite infections, suggesting improved diagnostics.

Cite This Study

Adilijiang Maimaitiming (2026) studied this question.

synapsesocial.com/papers/69d5f13674eaea4b11a7abc9 https://doi.org/10.1186/s12879-026-13222-9

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Metagenomic next-generation sequencing (mNGS) for severe cat bite infections with negative aerobic culture: a single-center retrospective study in a rabies vaccination center

Key Points

Discussion

Implication

Cite This Study

Metagenomic next-generation sequencing (mNGS) for severe cat bite infections with negative aerobic culture: a single-center retrospective study in a rabies vaccination center

Key Points

Discussion

Implication

Cite This Study

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