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April 8, 2026JAMA7 citations

Discontinuation of Levothyroxine in Adults Aged 60 Years or Older

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JRJanneke RavensbergLeiden University Medical CenterJGJacobijn GusseklooLeiden UniversitySCSaskia Le CessieLeiden University Medical Center

Key Points

  • To assess the discontinuation rates of levothyroxine in adults aged 60 years or older while maintaining thyroid function.
  • Open-label, single-group prospective study
  • Population included adults aged 60 years or older
  • Evaluated thyroid function over one year
  • 25.7% of participants discontinued levothyroxine after one year
  • Participants maintained adequate thyroid function during the study
  • Particular focus on those taking 50 µg/d or lower doses

Abstract

In this open-label, single-group prospective study, 25.7% of adults aged 60 years or older discontinued levothyroxine treatment while maintaining adequate thyroid function at 1 year. Evaluation of the need to continue levothyroxine should be considered in adults aged 60 years or older, particularly in those taking a dose of 50 µg/d or lower.

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Cite This Study

Ravensberg et al. (2026) studied this question.

synapsesocial.com/papers/69d5f13674eaea4b11a7abefhttps://doi.org/10.1001/jama.2026.2864
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