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July 27, 2026Drug and Therapeutics Bulletin

Discontinuation of levothyroxine in older adults

BMJ Publishing Group Ltd

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Key Points

This research aims to evaluate the effects and safety of discontinuing levothyroxine in individuals aged 60 and above.
Involved older adults aged 60 years or more
Analyzed the impact on thyroid hormone levels
Discontinuation of levothyroxine resulted in significant changes in thyroid hormone levels
Adverse events were monitored, revealing a safe profile for discontinuation
Findings suggest care considerations when managing levothyroxine therapy in older adults

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Implication

Examines thyroid hormone discontinuation in older adults, suggesting potential health impacts.

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Cite This Study

BMJ Publishing Group Ltd (2026) studied this question.

synapsesocial.com/papers/6a69a28ac8da07d9defa6025 https://doi.org/10.1136/dtb.2026.000030

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Discontinuation of Levothyroxine in Adults Aged 60 Years or OlderCohort Study · 2026 · 7 citations
2Assessing the Cardiovascular Effects of Levothyroxine Use in an Ageing UK Population with Subclinical Hypothyroidism: Emulated Target Trial (ACEL-UK-ETT)Randomized Controlled Trial · 2026 · 1 citations
3Levothyroxine for subclinical hypothyroidism in older adults: no evidence of benefit on quality of life or cardiovascular outcomes: a systematic reviewSystematic Review · 2026 · 1 citations
4Patient-Reported Satisfaction with Thyroid Hormone Replacement Therapy for Subclinical Hypothyroidism in Older Adults: A Pooled Analysis of Individual Participant Data from Two Randomized Controlled Trials2024 · 1 citations
5Weight-based levothyroxine dosing and long-term cardiovascular, bone, and mortality outcomes in older adults: an emulated target trial using UK primary care dataHuman Clinical Trial · 2026

More related papers

Navigating Thyroid Hormone Deprescribing in Older Adults2026
Levothyroxine treatment and incident dementia in adults with atrial fibrillation2019
Levothyroxine treatment response of cardiometabolic biomarkers in older adults with subclinical hypothyroidism2026

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