Neutrophil infiltration is actively associated with acute coronary events, with higher levels in ruptured compared to eroded plaques.
NEP-positive neutrophils may distinguish rupture from erosion mechanisms; leaves open therapeutic targeting in ACS.
The observations suggest that neutrophil infiltration is actively associated with acute coronary events. The high number of NEP-positive neutrophils in ruptured plaques, compared with eroded plaques, may reflect differences in the underlying pathophysiological mechanisms.
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Naruko et al. (2002) studied this question.
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