The relationship between body mass index, treatment, and mortality in patients with established coronary artery disease: a report from APPROACH
Why the study?
Is higher body mass index associated with improved survival in patients with established coronary artery disease across different treatment strategies?
Population
31,021 patients with established coronary artery disease from the Alberta Provincial Project for Outcome…
Comparison
Overweight and obese BMI categories vs Normal BMI (18.5-24.9 kg/m²)
Design
Cohort
Follow-up
median 46 months
Authors
Discussion
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Member takes
Implication
Should not alter weight management in CAD; leaves open confounding versus causal obesity paradox.
Structured PICO
Is higher body mass index associated with improved survival in patients with established coronary artery disease across different treatment strategies?
P
Population
31,021 patients with established coronary artery disease from the Alberta Provincial Project for Outcome Assessment in Coronary Heart Disease (APPROACH) registry
I
Intervention
Overweight and obese BMI categories (25.0-39.9 kg/m²)
C
Comparator
Normal BMI (18.5-24.9 kg/m²)
O
Outcome
Mortalityhard clinical
A paradoxical association exists between higher BMI and improved survival in patients with established CAD, irrespective of whether they are treated medically or with revascularization.
Cite This Study
Oreopoulos et al. (2009) studied this question.