What question did this study set out to answer?

To establish and assess the safety of an outpatient, ambulant controlled human infection model using escalating challenge doses of virulent Salmonella Typhi in sodium bicarbonate solution.

February 10, 2014Clinical Infectious DiseasesOpen Access

An Outpatient, Ambulant-Design, Controlled Human Infection Model Using Escalating Doses of Salmonella Typhi Challenge Delivered in Sodium Bicarbonate Solution

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To establish and assess the safety of an outpatient, ambulant controlled human infection model using escalating challenge doses of virulent Salmonella Typhi in sodium bicarbonate solution.
Administered small, escalating challenge doses of virulent S. Typhi suspended in sodium bicarbonate solution.
Implemented an outpatient, ambulant-design protocol to evaluate host-pathogen interactions and immune responses.
Outpatient administration of virulent S. Typhi challenge was executed safely without requiring full inpatient confinement.
The ambulant challenge platform generated a viable model to advance the discovery and evaluation of typhoid diagnostics, vaccines, and therapeutics.

Implication

Human challenge study demonstrates safe outpatient administration of virulent Salmonella Typhi in healthy volunteers, highlighting a platform to accelerate vaccine and diagnostic testing.

Abstract

Human challenge with a small inoculum of virulent S. Typhi administered in bicarbonate solution can be performed safely using an ambulant-model design to advance understanding of host-pathogen interactions and immunity. This model should expedite development of diagnostics, vaccines, and therapeutics for typhoid control.

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Cite This Study

Waddington et al. (2014) studied this question.

synapsesocial.com/papers/69d6c080fca0359822aa8346 https://doi.org/10.1093/cid/ciu078

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Implication

Human challenge study demonstrates safe outpatient administration of virulent Salmonella Typhi in healthy volunteers, highlighting a platform to accelerate vaccine and diagnostic testing.

An Outpatient, Ambulant-Design, Controlled Human Infection Model Using Escalating Doses of Salmonella Typhi Challenge Delivered in Sodium Bicarbonate Solution

Key Points

Implication

Abstract

Discussion

Cite This Study

An Outpatient, Ambulant-Design, Controlled Human Infection Model Using Escalating Doses of Salmonella Typhi Challenge Delivered in Sodium Bicarbonate Solution

Key Points

Implication

Abstract

Discussion

Cite This Study

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