The importance of distinguishing Mycoplasma pneumoniae-induced rash and mucositis (MIRM) and Stevens-Johnson syndrome in a clinical setting

Mycoplasma pneumoniae-induced rash and mucositis (MIRM) is a distinct entity from Stevens-Johnson syndrome/toxic epidermal necrolysis and erythema multiforme. As antibiotics may be prescribed in the context of MIRM, it is critical to differentiate drug hypersensitivity from Mycoplasma pneumoniae-sequelae to avoid incorrect drug allergy labeling. Patients may require evaluation by an immunologist for removal of a drug allergy label in cases of MIRM through clinical evaluation with or without a protocolised drug challenge.