Hematological and Immunological parameters in apparently healthy people in Ethiopia: Systematic review and meta-analysis

Background: Hematological and immunological parameters are fundamental components of person's health assessment.Quantitative determination of normal reference range of hematological and immunological parameters of apparently health people used to assist diagnosis of various diseases.The reference values currently used in Asia and Africa have been obtained from researches on populations in developed countries and may not be applicable in most local settings.The local reference values for immunohematological parameters are essential components of evidence based medicine.Objectives: The aim of the present study was to review exiting literatures and establishing normal reference range of hematological and immunological parameters in Ethiopia.Result: Meta-analysis by random effect model showed that the estimated pooled mean and 95% CI of red blood cells, white blood cells, and platelets in males was 5.29 x 1012/l (95% CI; 5.15-5.44x 1012/l) respectively while the mean and 95% CI of red blood cells, white blood cells, and platelets in females was 4.77 x 1012/l (95% CI; 4.61-4.94x 1012/l) respectively.Conclusion: the estimated pooled mean and 95% CI of hematological and immunological parameters showed some degree of difference with reference range adopted from developed country.