Why the study?
Does captopril combined with nitrate improve ventricular refractoriness and repolarisation compared to hydralazine combined with nitrate in patients with left ventricular dysfunction and inducible ventricular tachycardia?
Does captopril combined with nitrate improve ventricular refractoriness and repolarisation compared to hydralazine combined with nitrate in patients with left ventricular dysfunction and inducible ventricular tachycardia?
Captopril combined with nitrate prolongs ventricular refractoriness and repolarization in patients with LV dysfunction and inducible VT, an effect not seen with hydralazine.
Captopril-nitrate may prolong refractoriness in LV dysfunction with inducible VT; leaves open arrhythmia outcome implications versus hydralazine-nitrate.
Load manipulation by captopril but not hydralazine combined with nitrate prolonged ventricular refractoriness and repolarisation, possibly reflecting a combination of mechano-electrical effect with the restraining influence of ACE inhibitors on reflex sympathetic stimulation.
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Bashir et al. (1992) studied this question.
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