Why the study?
Does load manipulation alter myocardial excitability and refractoriness in the in situ pig heart?
Population
Anaesthetized, in situ pig heart
Comparison
Load manipulation vs Baseline/different load states
Design
Preclinical
Authors
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May promote load-dependent arrhythmogenesis in heart failure; hypothesis-generating in pigs and requires human validation before clinical relevance.
Does load manipulation alter myocardial excitability and refractoriness in the in situ pig heart?
Mechanical load manipulation directly alters regional ventricular refractoriness, suggesting a mechanism for arrhythmogenesis in high-load states like heart failure.
Dean et al. (1990) studied this question.
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