Why the study?
Synthetic and some endogenous circular RNAs can encode proteins, raising the promise of circRNA as a platform for gene expression.
Optimizing key elements of synthetic circular RNAs improves protein yields by several hundred-fold and provides more durable translation in vivo compared to mRNA.
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May advance circRNA therapeutics in preclinical models; leaves open translation to human applications.
Chen et al. (2022) studied this question.
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