What question did this study set out to answer?

To review the biological properties of chemokines and their receptors and delineate their roles in driving pathology in selected clinical disorders.

February 8, 2006New England Journal of Medicine

The Many Roles of Chemokines and Chemokine Receptors in Inflammation

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Authors

ICIsrael CharoBoston Children's Hospital RRRichard M. RansohoffNorthwestern University

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Implication

Narrative review outlines the mechanisms of chemokines in inflammatory responses, highlighting their therapeutic relevance across selected clinical disorders.

Key Points

To review the biological properties of chemokines and their receptors and delineate their roles in driving pathology in selected clinical disorders.
Reviewed biological literature detailing the structure and function of chemokines and chemokine receptors.
Assessed cellular mechanisms by which chemoattractants orchestrate immune cell migration during inflammatory disease states.
Chemokines and their corresponding receptors function as primary chemoattractants coordinating leukocyte trafficking and activation during inflammatory processes.
Aberrant expression or activation of chemokine signaling networks is linked directly to the pathogenesis of specific acute and chronic clinical inflammatory disorders.

Cite This Study

Charo et al. (2006) studied this question.

synapsesocial.com/papers/69d6cee8e328128020aa85f5 https://doi.org/10.1056/nejmra052723

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Implication

Narrative review outlines the mechanisms of chemokines in inflammatory responses, highlighting their therapeutic relevance across selected clinical disorders.

The Many Roles of Chemokines and Chemokine Receptors in Inflammation

Discussion

Member takes

Implication

Key Points

Cite This Study

The Many Roles of Chemokines and Chemokine Receptors in Inflammation

Discussion

Member takes

Implication

Key Points

Cite This Study

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