What question did this study set out to answer?

To review recent advances in understanding how chemokines and their receptors orchestrate immune cell migration and regulate adaptive immune responses during homeostasis and inflammation.

March 21, 2014Annual Review of ImmunologyOpen Access

Chemokines and Chemokine Receptors: Positioning Cells for Host Defense and Immunity

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To review recent advances in understanding how chemokines and their receptors orchestrate immune cell migration and regulate adaptive immune responses during homeostasis and inflammation.
Synthesized findings on the network of approximately 50 endogenous chemokine ligands and 20 G protein-coupled seven-transmembrane signaling receptors across lymphoid and peripheral tissues.
Chemokine networks control the directional migration and tissue-specific positioning of immune cells during both normal homeostasis and acute inflammation.
Chemokine receptor signaling directs critical adaptive immune processes, including naive T cell priming, effector and memory cell differentiation, and regulatory T cell function.

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Implication

Review reveals how chemokine signaling coordinates immune cell positioning across homeostatic and inflammatory states, highlighting its essential role in shaping adaptive immune responses.

Cite This Study

Griffith et al. (2014) studied this question.

synapsesocial.com/papers/69d8a8c3ce048d2571bed8ac https://doi.org/10.1146/annurev-immunol-032713-120145

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Implication

Review reveals how chemokine signaling coordinates immune cell positioning across homeostatic and inflammatory states, highlighting its essential role in shaping adaptive immune responses.

Chemokines and Chemokine Receptors: Positioning Cells for Host Defense and Immunity

Key Points

Discussion

Implication

Cite This Study

Chemokines and Chemokine Receptors: Positioning Cells for Host Defense and Immunity

Key Points

Discussion

Implication

Cite This Study

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