What question did this study set out to answer?

To identify which cardiovascular and inflammatory biomarkers best predict long-term all-cause mortality following acute myocardial infarction.

August 1, 2017European Journal of Preventive Cardiology

GDF-15 and TRAIL-R2 are powerful predictors of long-term mortality in patients with acute myocardial infarction

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Authors

ESEmma SkauUppsala University EHEgil HenriksenVästmanlands sjukhus Västerås PWPhilippe WagnerUppsala University

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Implication

Prospective cohort study reveals GDF-15 and TRAIL-R2 independently predict long-term mortality in acute myocardial infarction patients, highlighting novel proteomic targets for risk stratification.

Key Points

To identify which cardiovascular and inflammatory biomarkers best predict long-term all-cause mortality following acute myocardial infarction.
Prospective cohort study evaluating 92 circulating biomarkers via the Proximity Extension Assay in 847 consecutive patients from the Västmanland Myocardial Infarction Study.
Patients had a mean age of 70 years (32.7% female) and were followed for a median duration of 6.9 years.
Multivariable Cox regression models evaluated biomarker associations with all-cause mortality after adjustment for established clinical risk factors and traditional cardiac biomarkers.
A total of 207 patients died during the median 6.9-year follow-up period, with GDF-15 and TRAIL-R2 showing the strongest associations with all-cause mortality.
Both GDF-15 (HR 1.25 per unit change, 95% CI 1.02–1.53, p = 0.031) and TRAIL-R2 (HR 1.37 per unit change, 95% CI 1.12–1.67, p = 0.002) were independent predictors of long-term mortality after comprehensive multivariable adjustment.
Adding GDF-15 and TRAIL-R2 to standard clinical risk factors yielded a cross-validated area under the receiver operating characteristic curve of 0.88 for predicting five-year mortality.

Cite This Study

Skau et al. (2017) studied this question.

synapsesocial.com/papers/69d6ebcb8dca315383ed951b https://doi.org/10.1177/2047487317725017

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Implication

Prospective cohort study reveals GDF-15 and TRAIL-R2 independently predict long-term mortality in acute myocardial infarction patients, highlighting novel proteomic targets for risk stratification.

GDF-15 and TRAIL-R2 are powerful predictors of long-term mortality in patients with acute myocardial infarction

Discussion

Member takes

Implication

Key Points

Cite This Study

GDF-15 and TRAIL-R2 are powerful predictors of long-term mortality in patients with acute myocardial infarction

Discussion

Member takes

Implication

Key Points

Cite This Study

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