Key result
High plasma GDF-15 levels are associated with a significantly increased risk of mortality (RR 6.08) compared to low levels in patients with acute coronary syndrome.
Why the study?
Do high plasma GDF-15 levels predict increased risk of mortality and recurrent MI in patients with acute coronary syndrome?
Meta-Analysis (n=8,903)
Do high plasma GDF-15 levels predict increased risk of mortality and recurrent MI in patients with acute coronary syndrome?
Relative Risk: 6.08 (95% CI 4.79–7.71)
p-value: p=<0.00001
High plasma GDF-15 levels are strongly associated with an increased risk of mortality and recurrent myocardial infarction in patients with acute coronary syndrome, suggesting its potential utility as a prognostic biomarker.
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Supports GDF-15 for ACS mortality risk stratification; leaves open incremental value over established models.
Zhang et al. (2016) conducted a meta-analysis in Acute coronary syndrome (n=8,903). High plasma GDF-15 levels vs. Low plasma GDF-15 levels was evaluated on Mortality (RR 6.08, 95% CI 4.79-7.71, p=<0.00001). High plasma GDF-15 levels are associated with a significantly increased risk of mortality (RR 6.08) compared to low levels in patients with acute coronary syndrome.
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