Key result
Higher GDF-15 concentrations at hospital discharge after ACS were independently associated with an increased 2-year risk of death or MI (adjusted HR per ln increase 2.1; 95% CI 1.6-2.9; P<0.001).
Why the study?
Does GDF-15 concentration at hospital discharge predict the risk of recurrent events in patients stabilized after acute coronary syndrome?
Cohort (n=3,501)
Does GDF-15 concentration at hospital discharge predict the risk of recurrent events in patients stabilized after acute coronary syndrome?
Effect estimate: adjusted HR 2.1 (95% CI 1.6 to 2.9)
p-value: p=<0.001
GDF-15 measured at hospital discharge is a strong, independent prognostic marker for recurrent events (death, MI, heart failure) in patients stabilized after ACS.
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Supports GDF-15 for post-ACS prognostication; leaves open whether it refines risk models or guides therapy.
Bonaca et al. (2010) conducted a cohort in Acute Coronary Syndrome (n=3,501). GDF-15 vs. <1200, 1200-1800, and >1800 ng/L was evaluated on death or MI (adjusted HR 2.1, 95% CI 1.6 to 2.9, p=<0.001). Higher GDF-15 concentrations at hospital discharge after ACS were independently associated with an increased 2-year risk of death or MI (adjusted HR per ln increase 2.1; 95% CI 1.6-2.9; P<0.001).
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