What question did this study set out to answer?

To assess the prevalence and pathological relevance of Lewy bodies across aging non-parkinsonian individuals to elucidate the origins and development of Parkinson's disease.

June 1, 1988Journal of Neurology Neurosurgery & PsychiatryOpen Access

The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson's disease.

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To assess the prevalence and pathological relevance of Lewy bodies across aging non-parkinsonian individuals to elucidate the origins and development of Parkinson's disease.
Postmortem neuropathological evaluation of 273 brains from patients dying of disorders other than Parkinson's disease (N=273).
Histological assessment of Lewy body formation and structural neurofilament alterations across selective brain regions including the substantia nigra.
Age-specific prevalence of incidental Lewy bodies increased from 3.8% in the sixth decade to 12.8% in the ninth decade of life.
Pathological characteristics of incidental Lewy body disease indicate that these cases represent an early, presymptomatic stage of Parkinson's disease driven primarily by endogenous, time-dependent mechanisms.

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Implication

Autopsy study reveals age-related increases in incidental Lewy bodies among individuals without Parkinson's disease, suggesting an endogenous, presymptomatic phase of neurodegeneration.

Cite This Study

Gibb et al. (1988) studied this question.

synapsesocial.com/papers/69d6f64d8dca315383ed9622 https://doi.org/10.1136/jnnp.51.6.745

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Implication

Autopsy study reveals age-related increases in incidental Lewy bodies among individuals without Parkinson's disease, suggesting an endogenous, presymptomatic phase of neurodegeneration.

The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson's disease.

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Discussion

Implication

Cite This Study

The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson's disease.

Key Points

Discussion

Implication

Cite This Study

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