What question did this study set out to answer?

To determine whether an association exists between Parkinson's disease and Alzheimer's disease by analyzing the age-specific prevalence of nigral Lewy bodies.

June 1, 1989Journal of Neurology Neurosurgery & PsychiatryOpen Access

A pathological study of the association between Lewy body disease and Alzheimer's disease.

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Authors

WGW R GibbNorthwestern University CMC.Q. MountjoyAddenbrooke's Hospital DMDavid MannBoston University

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Implication

Pathological study reveals elevated Lewy body prevalence in Alzheimer's disease, suggesting additive pathological burdens drive dementia rather than a shared disease etiology.

Key Points

To determine whether an association exists between Parkinson's disease and Alzheimer's disease by analyzing the age-specific prevalence of nigral Lewy bodies.
Examined postmortem brain tissue from 273 controls without Parkinson's disease, 121 cases of Alzheimer's disease, and 14 cases of Down's syndrome (13 exhibiting cortical Alzheimer pathology).
Evaluated Lewy body presence and neuronal loss in the substantia nigra, quantified neurofibrillary tangles and plaques across cortical regions, and measured cortical choline acetyltransferase (ChAT) activity.
Nigral Lewy bodies were observed in 22.5% (25/111) of Alzheimer's disease cases over 60 years of age compared to 7.8% (12/154) of control cases, while 0% (0/14) of Down's syndrome cases had Lewy bodies.
Alzheimer's cases with Lewy bodies had lower counts of tangles and plaques in the hippocampus, frontal cortex, and temporal cortex compared to cases without Lewy bodies, despite showing similar cortical ChAT enzyme activities.

Cite This Study

Gibb et al. (1989) studied this question.

synapsesocial.com/papers/6a186a8b1ca866914fc99c91 https://doi.org/10.1136/jnnp.52.6.701

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Implication

Pathological study reveals elevated Lewy body prevalence in Alzheimer's disease, suggesting additive pathological burdens drive dementia rather than a shared disease etiology.

A pathological study of the association between Lewy body disease and Alzheimer's disease.

Discussion

Member takes

Implication

Key Points

Cite This Study

A pathological study of the association between Lewy body disease and Alzheimer's disease.

Discussion

Member takes

Implication

Key Points

Cite This Study

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