Up to 60% of Alzheimer's disease cases have Lewy body pathology. In Alzheimer's disease, Lewy body pathology is associated with more rapid cognitive decline, parkinsonism, and younger symptom onset. In this abstract, we examine nigral volume in Alzheimer's disease patients and patients with mild cognitive impairment with Lewy body pathology. We find that cognitively impaired patients with Lewy bodies have greater neuronal loss in substantia nigra pars compacta as well as reduced nigral volume.
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Langley et al. (2024) studied this question.
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