Study protocol of the WashT Trial: transfusion with washed versus unwashed red blood cells to reduce morbidity and mortality in infants born less than 28 weeks’ gestation - a multicentre, blinded, parallel group, randomised controlled trial

Michael J. Stark; Carmel T Collins; Chad Andersen; Tara M. Crawford; Thomas Sullivan; Jana Bednarz; Rachael L. Morton; Denese C. Marks; Mbathio Dieng; Louise Owen; Gillian Opie; Javeed Travadi; Kenneth Tan; Scott A. Morris

doi:10.1136/bmjopen-2022-070272

July 1, 2023SHILAP Revista de lepidopterologíaOpen Access

Study protocol of the WashT Trial: transfusion with washed versus unwashed red blood cells to reduce morbidity and mortality in infants born less than 28 weeks’ gestation - a multicentre, blinded, parallel group, randomised controlled trial

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Key Points

To evaluate whether transfusion with washed red blood cells compared to unwashed red blood cells reduces morbidity and mortality in extremely preterm infants born at less than 28 weeks of gestation.
Multicentre, blinded, parallel-group, randomised controlled trial design (WashT Trial; ACTRN12613000237785).
Infants born at less than 28 weeks' gestation requiring transfusion are randomly assigned to receive either washed or unwashed red blood cells.
Protocol description detailing the trial design, allocation, and planned safety analyses.
Primary and secondary outcomes comparing morbidity and mortality between washed and unwashed transfusion arms are pending completion of the trial.

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Implication

Randomized trial protocol reports trial design evaluating washed versus unwashed blood transfusions in extremely preterm infants, highlighting potential reductions in neonatal mortality.

Abstract

ACTRN12613000237785 Australian New Zealand Clinical Trials Registry.

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Stark et al. (2023) studied this question.

synapsesocial.com/papers/69d6fa2665989f52c9ab30e5 https://doi.org/10.1136/bmjopen-2022-070272

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Study protocol of the WashT Trial: transfusion with washed versus unwashed red blood cells to reduce morbidity and mortality in infants born less than 28 weeks’ gestation - a multicentre, blinded, parallel group, randomised controlled trial

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Cite This Study

Study protocol of the WashT Trial: transfusion with washed versus unwashed red blood cells to reduce morbidity and mortality in infants born less than 28 weeks’ gestation - a multicentre, blinded, parallel group, randomised controlled trial

Key Points

No abstract yet

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Discussion

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