March 16, 2005Journal of Applied Physiology
The anti-inflammatory effect of exercise
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Discussion
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Implication
Review reveals how muscle-derived interleukin-6 suppresses systemic inflammation during exercise, suggesting myokines protect against cardiovascular disease and diabetes.
Key Points
- To review the mechanisms by which exercise exerts anti-inflammatory effects and evaluate the protective role of muscle-derived cytokines against chronic metabolic diseases.
- Narrative synthesis of molecular pathways linking physical activity, adipose tissue signaling, and cytokine release.
- Evaluation of endocrine signaling by skeletal muscle fibers during contraction compared to systemic cytokine responses in chronic disease.
- Contracting skeletal muscle fibers secrete interleukin-6 (IL-6) via a tumor necrosis factor-alpha (TNF-α)-independent pathway, which stimulates anti-inflammatory mediators (IL-1ra, IL-10) and suppresses pro-inflammatory TNF-α.
- Muscle-derived IL-6 acts as a myokine to stimulate lipolysis and fat oxidation, thereby countering TNF-α-mediated insulin resistance and metabolic dysfunction.
Cite This Study
Petersen et al. (2005) studied this question.