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June 6, 2012The LancetOpen Access

Radiation exposure from CT scans in childhood and subsequent risk of leukaemia and brain tumours: a retrospective cohort study

Mark S. Pearce Jane A Salotti Mark P. Little Kieran McHugh Choonsik Lee Kwang Pyo Kim Nicola Howe Cécile M. Ronckers Preetha Rajaraman Alan Craft Louise Parker Amy Berrington de González

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Key Points

To investigate the relationship between radiation exposure from CT scans during childhood and the risk of leukaemia and brain tumours.
Retrospective cohort study conducted using data from the US National Cancer Institute and UK Department of Health.
Analyzed childhood CT scan records and subsequent cancer diagnoses.
Identified a significant association between CT scan radiation exposure and increased incidence of leukaemia.
Demonstrated a heightened risk for brain tumours correlated with the number of CT scans received.

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Implication

Retrospective cohort study shows increased risk of leukaemia and brain tumours from CT scans in children, indicating health concerns.

Abstract

US National Cancer Institute and UK Department of Health.

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Cite This Study

Pearce et al. (2012) studied this question.

synapsesocial.com/papers/69d709f31a8b22ff6fab3165 https://doi.org/10.1016/s0140-6736(12)60815-0

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Early life exposure to diagnostic radiation and ultrasound scans and risk of childhood cancer: case-control studyCase-Control Study · 2011 · 118 citations
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3Factors Associated With CT Scan Repetition in Pediatrics and Its Relationship With Cancer Risk: A Systematic Review and Meta-AnalysisMeta-Analysis · 2026 · 1 citations
4Medical Imaging and Pediatric and Adolescent Hematologic Cancer Risk2025 · 91 citations
5Solar ultraviolet radiation exposure, and incidence of childhood (0–19 years) malignant and non-malignant brain tumour in a US population-based dataset, 2000–20212025

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