Contractile Function During Angiotensin-II Activation
Population
cardiomyocytes
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Should not alter clinical practice; leaves open Nox2 as a therapeutic target in RAS-activated cardiac dysfunction.
Structured PICO
P
Population
cardiomyocytes
I
Intervention
Angiotensin-II activation
O
Outcome
cardiomyocyte SR Ca(2+) uptake and contractile functionsurrogate
Identifies a novel Nox2-dependent mechanism regulating cardiomyocyte contractility via phospholamban phosphorylation during renin-angiotensin system activation.
Cite This Study
Zhang et al. (2015) studied this question.