Why the study?
Does preventing PKA phosphorylation of RyR2 at Ser-2808 protect against the development of heart failure after myocardial infarction in mice?
Population
RyR2-S2808A mice subjected to myocardial infarction
Comparison
Genetic mutation preventing PKA phosphorylation… vs Wild-type mice (implied)
Design
Preclinical
Authors
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Animal data implicate RyR2 phosphorylation in post-MI remodeling; hypothesis-generating and should not alter clinical practice.
Does preventing PKA phosphorylation of RyR2 at Ser-2808 protect against the development of heart failure after myocardial infarction in mice?
PKA phosphorylation of Ser-2808 on the RyR2 channel is a critical mediator of progressive cardiac dysfunction after myocardial infarction, and preventing it protects against heart failure in a mouse model.
Wehrens et al. (2006) studied this question.
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