September 1, 1995Circulation
Alterations in Intracellular Calcium Handling Associated With the Inverse Force-Frequency Relation in Human Dilated Cardiomyopathy
Why the study?
Does altered intracellular calcium handling explain the inverse force-frequency relation in human failing dilated cardiomyopathy?
Population
Ventricular muscle strip preparations from 5 nonfailing human hearts and 7 hearts with end-stage failing…
Comparison
Stepwise increase in stimulation frequency from… vs Nonfailing human hearts
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Altered calcium handling may underlie force-frequency reversal in failing hearts; leaves open human validation before clinical relevance.
Structured PICO
Does altered intracellular calcium handling explain the inverse force-frequency relation in human failing dilated cardiomyopathy?
P
Population
Ventricular muscle strip preparations from 5 nonfailing human hearts and 7 hearts with end-stage failing dilated cardiomyopathy (n=12 hearts total)
I
Intervention
Stepwise increase in stimulation frequency from 15 to 180 beats per minute
C
Comparator
Nonfailing human hearts
O
Outcome
Force-frequency relation (isometric twitch tension) and intracellular calcium cycling (aequorin light emission)surrogate
The inverse force-frequency relation in failing human myocardium is associated with disturbed excitation-contraction coupling and decreased calcium cycling at higher stimulation rates.
Cite This Study
Pieske et al. (1995) studied this question.