January 19, 2010Open Access

Uncoupled Cardiac Nitric Oxide Synthase Mediates Diastolic Dysfunction

Structured PICO

Intervention

BH(4)

Outcome

Diastolic dysfunction and uncoupled cardiac NOSsurrogate

Cardiac oxidation independently leads to uncoupled cardiac NOS and diastolic dysfunction, suggesting BH(4) as a potential therapeutic target.

Abstract

Cardiac oxidation, independently of vascular changes, can lead to uncoupled cardiac NOS and diastolic dysfunction. BH(4) may represent a possible treatment for diastolic dysfunction.

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Cite This Study

Silberman et al. (Tue,) studied this question.

synapsesocial.com/papers/69d722438a0e2c5879bef5d1 https://doi.org/https://doi.org/10.1161/circulationaha.109.883777

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