Does the presence of a high-risk plaque predict worse clinical outcomes in patients with MI and FFR-negative nonculprit lesions?
High-risk plaques in FFR-negative nonculprit lesions are associated with worse clinical outcomes after MI, suggesting a need for additional targeted therapies.
Among patients with MI and FFR-negative nonculprit lesions, the presence of a high-risk plaque is associated with a worse clinical outcome, which is mainly driven by a higher number of unplanned revascularizations. In a population with a high recurrent event rate despite physiology-guided complete revascularization, these results call for research on additional pharmacological or focal treatment strategies in patients harboring high-risk plaques.
Mol et al. (Wed,) studied this question.