What question did this study set out to answer?

Synthesize current knowledge on the cellular and molecular mechanisms driving cardiac fibrosis, along with available diagnostic tools and emerging therapeutic strategies.

May 31, 2019Advanced Drug Delivery ReviewsOpen Access

Cardiac fibrosis – A short review of causes and therapeutic strategies

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Why the study?

Fibrotic diseases cause substantial global mortality, with cardiac fibrosis leading to stiffened myocardial matrix, reduced ejection fraction, impaired electric conductance, and death through diverse scar types.

Key Points

Synthesize current knowledge on the cellular and molecular mechanisms driving cardiac fibrosis, along with available diagnostic tools and emerging therapeutic strategies.
Literature synthesis examining extracellular matrix remodeling triggered by aging, myocardial injury, and cardiovascular disease.
Evaluation of preclinical and clinical interventions designed to target cardiac scar formation and improve functional outcomes.
Pathological remodeling of the myocardial extracellular matrix generates distinct scar phenotypes that impair cardiac electrical conductance and diminish ventricular ejection fraction.
Targeted antifibrotic interventions in preclinical and clinical stages focus on modulating specific cardiac cell populations to halt or reverse adverse structural remodeling.

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Implication

May guide research priorities in cardiac fibrosis; leaves open clinical translation pending prospective validation.

Cite This Study

Hinderer et al. (2019) studied this question.

synapsesocial.com/papers/69d72a80b6c880d6aaf508ff https://doi.org/10.1016/j.addr.2019.05.011

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Cardiac fibrosis – A short review of causes and therapeutic strategies

Key Points

Discussion

Implication

Cite This Study

Cardiac fibrosis – A short review of causes and therapeutic strategies

Key Points

Discussion

Implication

Cite This Study

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