Does digoxin therapy have sex-based differences in mortality risk in patients with heart failure and depressed left ventricular systolic function?
Digoxin therapy is associated with increased all-cause mortality in women with heart failure and reduced ejection fraction, highlighting a critical sex-based difference in safety.
The effect of digoxin therapy differs between men and women. Digoxin therapy is associated with an increased risk of death from any cause among women, but not men, with heart failure and depressed left ventricular systolic function.
Rathore et al. (2002) studied this question.