Genetic analysis reveals equivalent cardiovascular protection and diabetes risk per unit LDL cholesterol reduction for PCSK9 and HMGCR variants, indicating independent and additive mechanisms.
In this study, variants in PCSK9 had approximately the same effect as variants in HMGCR on the risk of cardiovascular events and diabetes per unit decrease in the LDL cholesterol level. The effects of these variants were independent and additive. (Funded by the Medical Research Council and the National Heart, Lung, and Blood Institute.).
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Ference et al. (2016) studied this question.
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