Key result
The PCSK5 genetic variant rs11144766 was significantly associated with low HDL-C levels in a combined analysis of 883 individuals (Bonferroni-adjusted P=0.031).
Why the study?
Do genetic variants at the PCSK5 locus influence plasma HDL-C levels in individuals with low HDL-C or coronary artery disease?
Observational (n=883)
Yes
Do genetic variants at the PCSK5 locus influence plasma HDL-C levels in individuals with low HDL-C or coronary artery disease?
p-value: p=0.031
Genetic variability at the PCSK5 locus is significantly associated with plasma HDL-C levels, suggesting a potential mechanism involving endothelial lipase inactivation that modulates ASCVD risk.
Association with low HDL-C is hypothesis-generating; leaves open causal links to ASCVD outcomes.
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Iatan et al. (2009) conducted an observational in Low HDL-C and coronary artery disease (n=883). PCSK5 genetic variants (rs11144766) was evaluated on Plasma HDL-C levels (p=0.031). The PCSK5 genetic variant rs11144766 was significantly associated with low HDL-C levels in a combined analysis of 883 individuals (Bonferroni-adjusted P=0.031).
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