Why the study?
Does the type of carotid body CO2 stimulus influence the ventilatory gain of central chemoreceptors to CO2 in awake dogs?
Does the type of carotid body CO2 stimulus influence the ventilatory gain of central chemoreceptors to CO2 in awake dogs?
Peripheral chemoreceptor CO2 levels determine the respiratory sensitivity of central chemoreceptors to CO2, demonstrating that hyperaddition is the dominant form of chemoreceptor interaction in quiet wakefulness.
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Peripheral CO2 levels may modulate central chemoreceptor gain in awake dogs; leaves open translation to human ventilatory control.
Smith et al. (2015) studied this question.
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