Why the study?
Hypertension affects approximately 116 million US adults and over 1 billion adults worldwide, serving as a leading cause of CVD morbidity and mortality.
Lifestyle modifications and specific first-line antihypertensive medications (thiazides, ACEi/ARBs, CCBs) are the foundation of hypertension management.
Supports guideline first-line hypertension therapy in practice; leaves open need for updated comparative trials.
Hypertension affects approximately 116 million adults in the US and more than 1 billion adults worldwide and is a leading cause of CVD morbidity and mortality. First-line therapy for hypertension is lifestyle modification, consisting of weight loss, dietary sodium reduction and potassium supplementation, healthy dietary pattern, physical activity, and limited alcohol consumption. When drug therapy is required, first-line therapies are thiazide or thiazidelike diuretics, angiotensin-converting enzyme inhibitor or angiotensin receptor blockers, and calcium channel blockers.
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Carey et al. (2022) studied this question.
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