What question did this study set out to answer?

To determine whether T1-weighted signal intensity increases in the dentate nucleus and globus pallidus depend on the specific class of gadolinium-based contrast agent administered.

April 7, 2015Radiology

Gadolinium Retention in the Dentate Nucleus and Globus Pallidus Is Dependent on the Class of Contrast Agent

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Authors

ARAlexander RadbruchUniversity of Bonn LWLukas D. WeberlingHeidelberg University PKPascal J. KieslichUniversity of Mannheim

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Implication

Comparative imaging study reveals signal increases in the dentate nucleus and globus pallidus after linear but not macrocyclic contrast agents, highlighting chemical class differences in brain...

Key Points

To determine whether T1-weighted signal intensity increases in the dentate nucleus and globus pallidus depend on the specific class of gadolinium-based contrast agent administered.
Assessed changes in signal intensity within the dentate nucleus (DN) and globus pallidus (GP) on unenhanced T1-weighted magnetic resonance images.
Compared serial applications of the linear gadolinium-based contrast agent gadopentetate dimeglumine against the macrocyclic agent gadoterate meglumine.
Serial administration of the linear GBCA gadopentetate dimeglumine caused a qualitative increase in T1-weighted signal intensity in both the dentate nucleus and globus pallidus.
Serial administration of the macrocyclic GBCA gadoterate meglumine produced no detectable signal intensity increase in either brain region.

Cite This Study

Radbruch et al. (2015) studied this question.

synapsesocial.com/papers/69d736aa447a5ff6a2b8a4f3 https://doi.org/10.1148/radiol.2015150337

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Implication

Comparative imaging study reveals signal increases in the dentate nucleus and globus pallidus after linear but not macrocyclic contrast agents, highlighting chemical class differences in brain...

Gadolinium Retention in the Dentate Nucleus and Globus Pallidus Is Dependent on the Class of Contrast Agent

Discussion

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Implication

Key Points

Cite This Study

Gadolinium Retention in the Dentate Nucleus and Globus Pallidus Is Dependent on the Class of Contrast Agent

Discussion

Member takes

Implication

Key Points

Cite This Study

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