What question did this study set out to answer?

To determine whether T1-weighted MR image hyperintensity in the dentate nucleus is associated with prior administration of linear versus macrocyclic gadolinium-based contrast agents.

January 29, 2015Radiology

High Signal Intensity in Dentate Nucleus on Unenhanced T1-weighted MR Images: Association with Linear versus Macrocyclic Gadolinium Chelate Administration

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Authors

TKTomonori KandaShiga University of Medical Science MOMarie OsawaNTT Medical Center HOHiroshi ObaKanazawa University

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Implication

Retrospective study reveals dentate nucleus T1 hyperintensity links to linear but not macrocyclic gadolinium exposure in brain MRI patients, indicating differential brain retention risks.

Key Points

To determine whether T1-weighted MR image hyperintensity in the dentate nucleus is associated with prior administration of linear versus macrocyclic gadolinium-based contrast agents.
Retrospective review of unenhanced T1-weighted brain MR images from 127 patients selected from 360 consecutive individuals who underwent contrast-enhanced brain MR imaging.
Two radiologists performed visual evaluations and region-of-interest signal intensity measurements to determine dentate nucleus-to-cerebellum (DN/cerebellum) ratios.
Multivariable generalized additive modeling with Akaike information criterion model selection evaluated associations with linear and macrocyclic exposures, and Lin concordance correlation coefficient assessed interobserver agreement.
Dentate nucleus hyperintensity appeared in 9 of 127 patients (7.1%), with almost perfect interobserver agreement (Lin concordance correlation coefficient: 0.992, 95% CI: 0.990 to 0.994).
The DN/cerebellum signal intensity ratio was significantly associated with previous linear GBCA administration (P < .001) but not with macrocyclic GBCA administration (P = .875).
Model selection using the Akaike information criterion retained only linear GBCA exposure in the final model as a factor associated with increased dentate nucleus signal intensity.

Cite This Study

Kanda et al. (2015) studied this question.

synapsesocial.com/papers/6a1d6ecb1024216094055b15 https://doi.org/10.1148/radiol.14140364

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Implication

Retrospective study reveals dentate nucleus T1 hyperintensity links to linear but not macrocyclic gadolinium exposure in brain MRI patients, indicating differential brain retention risks.

High Signal Intensity in Dentate Nucleus on Unenhanced T1-weighted MR Images: Association with Linear versus Macrocyclic Gadolinium Chelate Administration

Discussion

Member takes

Implication

Key Points

Cite This Study

High Signal Intensity in Dentate Nucleus on Unenhanced T1-weighted MR Images: Association with Linear versus Macrocyclic Gadolinium Chelate Administration

Discussion

Member takes

Implication

Key Points

Cite This Study

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