What question did this study set out to answer?

To estimate global, regional, and national trends in mean total, HDL, and non-HDL cholesterol levels across 200 countries between 1980 and 2018.

June 3, 2020NatureOpen Access

Repositioning of the global epicentre of non-optimal cholesterol

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Authors

CTCristina TaddeiNottingham University Hospitals NHS Trust BZBin ZhouSouth China Agricultural University HBHonor BixbySt George's, University of London

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Implication

Global pooled analysis reveals a geographical shift in high non-HDL cholesterol from Western Europe to Asia and Oceania, highlighting changing worldwide cardiovascular disease risks.

Key Points

To estimate global, regional, and national trends in mean total, HDL, and non-HDL cholesterol levels across 200 countries between 1980 and 2018.
Pooled data from 1,127 population-based studies measuring blood lipid profiles in 102.6 million adults aged 18 years and older across 200 countries.
Calculated trends from 1980 to 2018 for total, HDL, and non-HDL cholesterol and estimated the global mortality attributable to high non-HDL cholesterol in 2017.
Global mean total and non-HDL cholesterol remained largely unchanged from 1980 to 2018, as steep declines in high-income Western countries were balanced by rapid increases in East and Southeast Asia.
The highest non-HDL cholesterol levels shifted from northwestern European nations in 1980 to countries in Asia and the Pacific, including Malaysia, Thailand, and the Philippines.
High non-HDL cholesterol accounted for an estimated 3.9 million deaths (95% credible interval: 3.7 million–4.2 million) in 2017, with roughly half occurring in East, Southeast, and South Asia.

Cite This Study

Taddei et al. (2020) studied this question.

synapsesocial.com/papers/69d73ae635079b684748f5de https://doi.org/10.1038/s41586-020-2338-1

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Implication

Global pooled analysis reveals a geographical shift in high non-HDL cholesterol from Western Europe to Asia and Oceania, highlighting changing worldwide cardiovascular disease risks.

Repositioning of the global epicentre of non-optimal cholesterol

Discussion

Member takes

Implication

Key Points

Cite This Study

Repositioning of the global epicentre of non-optimal cholesterol

Discussion

Member takes

Implication

Key Points

Cite This Study

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