What question did this study set out to answer?

To review the terminology and quantification methods used to characterize circadian disruption and identify the challenges and limitations facing human research.

November 7, 2018European Journal of NeuroscienceOpen Access

Circadian disruption: What do we actually mean?

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Authors

CVCéline VetterUniversity of Colorado Boulder

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Implication

Review highlights inconsistencies in measuring circadian disruption in humans, suggesting standardized metrics are essential for clinical translation.

Key Points

To review the terminology and quantification methods used to characterize circadian disruption and identify the challenges and limitations facing human research.
Reviewed conceptual frameworks and terminology addressing acute and chronic challenges to the circadian system, such as transmeridian travel and rotating shift work.
Evaluated proposed quantification strategies and tools across experimental, observational, and mechanistic human and animal research settings.
Identified significant heterogeneity and ambiguity in the terminology used to describe transient and chronic circadian disturbances across disciplines.
Found that existing tools for quantifying circadian disruption exhibit major methodological limitations regarding scalability and operationalization.
Emphasized that robust, standardized measurement tools are required to improve reproducibility and translate mechanistic circadian findings into large-scale randomized clinical trials.

Cite This Study

Céline Vetter (2018) studied this question.

synapsesocial.com/papers/69d73fd2c74376700bf31153 https://doi.org/10.1111/ejn.14255

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Implication

Review highlights inconsistencies in measuring circadian disruption in humans, suggesting standardized metrics are essential for clinical translation.

Circadian disruption: What do we actually mean?

Discussion

Member takes

Implication

Key Points

Cite This Study

Circadian disruption: What do we actually mean?

Discussion

Member takes

Implication

Key Points

Cite This Study

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