Why the study?
Does the extent and distribution of myocardial fibrosis differ among patients with hypertrophic cardiomyopathy, hypertensive heart disease, and normal hearts?
Does the extent and distribution of myocardial fibrosis differ among patients with hypertrophic cardiomyopathy, hypertensive heart disease, and normal hearts?
Hypertrophic cardiomyopathy is associated with significantly greater and more widespread myocardial fibrosis compared to hypertensive heart disease and normal hearts, suggesting its pathogenesis involves factors beyond cardiac hypertrophy alone.
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Greater fibrosis distinguishes HCM pathogenesis from hypertrophy alone; cross-sectional data leave open diagnostic or prognostic utility pending prospective studies.
Tanaka et al. (1986) studied this question.
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