What question did this study set out to answer?

To determine the evolutionary origin of the oat beta-amyrin synthase gene AsbAS1 and characterize the genomic organization of the avenacin biosynthetic pathway.

May 17, 2004Proceedings of the National Academy of SciencesOpen Access

A gene cluster for secondary metabolism in oat: Implications for the evolution of metabolic diversity in plants

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Authors

XQXiaoquan QiChinese Academy of Sciences SBSaleha BakhtJohn Innes Centre MLMike LeggettAberystwyth University

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Implication

Comparative genomic analysis uncovers an operon-like biosynthetic gene cluster for antimicrobial avenacins in oats, highlighting how functional metabolic pathways evolve in plants.

Key Points

To determine the evolutionary origin of the oat beta-amyrin synthase gene AsbAS1 and characterize the genomic organization of the avenacin biosynthetic pathway.
Analyzed the evolutionary sequence divergence of the oat beta-amyrin synthase gene AsbAS1 relative to other plant oxidosqualene cyclases.
Characterized the genomic region surrounding AsbAS1 and compared synteny against other cereal genomes.
AsbAS1 arose through duplication and divergence of an ancestral cycloartenol synthase-like gene, with lineage-specific functional diversification occurring after oats diverged from wheat.
AsbAS1 is physically grouped with other non-homologous genes required for four distinct enzymatic steps in avenacin biosynthesis—cyclization, oxidation, glycosylation, and acylation—within a genomic region unique to oats.

Cite This Study

Qi et al. (2004) studied this question.

synapsesocial.com/papers/69d74d1b58d71cbec648f6d4 https://doi.org/10.1073/pnas.0401301101

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Implication

Comparative genomic analysis uncovers an operon-like biosynthetic gene cluster for antimicrobial avenacins in oats, highlighting how functional metabolic pathways evolve in plants.

A gene cluster for secondary metabolism in oat: Implications for the evolution of metabolic diversity in plants

Discussion

Member takes

Implication

Key Points

Cite This Study

A gene cluster for secondary metabolism in oat: Implications for the evolution of metabolic diversity in plants

Discussion

Member takes

Implication

Key Points

Cite This Study

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