What question did this study set out to answer?

Review the cellular mechanisms and physiological significance of microbiota-derived short-chain fatty acids (SCFAs) in intestinal barrier function, immunity, and overall human health.

April 2, 2020Proceedings of The Nutrition SocietyOpen Access

SCFA: mechanisms and functional importance in the gut

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Authors

CMCamille Martin‐GallausiauxInstitut Pasteur LMLudovica MarinelliGhent University HBHervé M. BlottièreUniversité Paris-Saclay

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Overview

Narrative review reveals how short-chain fatty acids maintain intestinal barrier integrity and immunity in humans, highlighting the therapeutic role of dietary fiber metabolites.

Key Points

Review the cellular mechanisms and physiological significance of microbiota-derived short-chain fatty acids (SCFAs) in intestinal barrier function, immunity, and overall human health.
Narrative review examining peer-reviewed literature on the human gut microbiota, microbial dysbiosis, and the fermentation pathways of dietary fiber into SCFAs.
Synthesis of molecular findings detailing the influence of acetate, propionate, and butyrate on intestinal epithelial cells, enteroendocrine cell populations, and immune responses.
Fermentation of dietary fibers yields SCFAs that serve as critical metabolic fuels for intestinal epithelial cells, steering cellular proliferation, differentiation, and tissue repair.
SCFAs regulate enteroendocrine signaling, promote normal gut motility, and fortify the epithelial barrier against luminal toxins and systemic translocation.
Butyrate exerts pronounced local and systemic immunomodulatory effects, suppressing aberrant inflammation and supporting host metabolic homeostasis.

Cite This Study

Martin‐Gallausiaux et al. (2020) studied this question.

synapsesocial.com/papers/69d75010447a5ff6a2b8a5ca https://doi.org/10.1017/s0029665120006916

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April 2, 2020Proceedings of The Nutrition SocietyOpen Access

SCFA: mechanisms and functional importance in the gut

View Full Paper

Ask AI

Bookmark

Authors

CMCamille Martin‐GallausiauxInstitut Pasteur LMLudovica MarinelliGhent University HBHervé M. BlottièreUniversité Paris-Saclay

Discussion

Member takes

Overview

Narrative review reveals how short-chain fatty acids maintain intestinal barrier integrity and immunity in humans, highlighting the therapeutic role of dietary fiber metabolites.

Key Points

Review the cellular mechanisms and physiological significance of microbiota-derived short-chain fatty acids (SCFAs) in intestinal barrier function, immunity, and overall human health.
Narrative review examining peer-reviewed literature on the human gut microbiota, microbial dysbiosis, and the fermentation pathways of dietary fiber into SCFAs.
Synthesis of molecular findings detailing the influence of acetate, propionate, and butyrate on intestinal epithelial cells, enteroendocrine cell populations, and immune responses.
Fermentation of dietary fibers yields SCFAs that serve as critical metabolic fuels for intestinal epithelial cells, steering cellular proliferation, differentiation, and tissue repair.
SCFAs regulate enteroendocrine signaling, promote normal gut motility, and fortify the epithelial barrier against luminal toxins and systemic translocation.
Butyrate exerts pronounced local and systemic immunomodulatory effects, suppressing aberrant inflammation and supporting host metabolic homeostasis.

Cite This Study

Martin‐Gallausiaux et al. (2020) studied this question.

synapsesocial.com/papers/69d75010447a5ff6a2b8a5ca https://doi.org/10.1017/s0029665120006916

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