Why the study?
Does retrograde aortic isthmus net blood flow alter fetal cardiac hemodynamics in placental insufficiency compared to antegrade flow?
Does retrograde aortic isthmus net blood flow alter fetal cardiac hemodynamics in placental insufficiency compared to antegrade flow?
In fetuses with placental insufficiency, retrograde aortic isthmus net blood flow is associated with a failure of adaptive hemodynamic shifts, suggesting reduced oxygen delivery to the left ventricle.
Signals failed adaptation in placental insufficiency; hypothesis-generating for AoI flow as prognostic marker, needs prospective validation.
In placental insufficiency, fetuses with antegrade AoI net blood flow show a shift in RVCO from the pulmonary to the systemic circulation, and Q(FO) makes up the majority of LVCO. Fetuses with retrograde AoI net blood flow fail to demonstrate these changes, suggesting a relative drop in the oxygen content of the blood entering the left ventricle.
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Mäkikallio et al. (2003) studied this question.
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