Why the study?
Does sustained dietary nitrate ingestion improve vascular function in patients with hypercholesterolemia?
Does sustained dietary nitrate ingestion improve vascular function in patients with hypercholesterolemia?
Sustained dietary nitrate improves vascular function and alters the oral microbiome in hypercholesterolemic patients, suggesting potential as a preventative strategy against atherogenesis.
May support nitrate-rich diets as adjunctive vascular protection in hypercholesterolemia; extends RCT evidence on oral microbiome effects.
Sustained dietary nitrate ingestion improves vascular function in hypercholesterolemic patients. These changes are associated with alterations in the oral microbiome and, in particular, nitrate-reducing genera. Our findings provide additional support for the assessment of the potential of dietary nitrate as a preventative strategy against atherogenesis in larger cohorts. This trial was registered at clinicaltrials.gov as NCT01493752.
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Velmurugan et al. (2015) studied this question.
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