What question did this study set out to answer?

To provide an upgraded, user-friendly computational web platform that improves the estimation and exploration of tumor-infiltrating immune cells across complex cancer datasets.

May 17, 2020Nucleic Acids ResearchOpen Access

TIMER2.0 for analysis of tumor-infiltrating immune cells

View Full Paper

Ask AI

Bookmark

To provide an upgraded, user-friendly computational web platform that improves the estimation and exploration of tumor-infiltrating immune cells across complex cancer datasets.
Integrated six state-of-the-art computational deconvolution algorithms to infer immune cell composition from bulk tumor transcriptome data.
Built eight dedicated analytical modules using The Cancer Genome Atlas (TCGA) cohorts and user-submitted expression profiles to evaluate associations between immune infiltrates, genomic alterations, and clinical features.
TIMER2.0 generates multi-algorithm immune infiltrate estimations that overcome the limitations and variability of single-method computational approaches.
The platform outputs standardized, interactive heatmap tables that simultaneously reveal significant tumor-immune and clinical correlations across multiple cancer types.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Bioinformatic platform development demonstrates robust immune cell infiltration profiling across diverse cancer types, highlighting actionable tumor-immune interactions.

Cite This Study

Li et al. (2020) studied this question.

synapsesocial.com/papers/69d75bf0f44a16d01ef307c6 https://doi.org/10.1093/nar/gkaa407

View Full Paper

Ask AI

Bookmark

Implication

Bioinformatic platform development demonstrates robust immune cell infiltration profiling across diverse cancer types, highlighting actionable tumor-immune interactions.

TIMER2.0 for analysis of tumor-infiltrating immune cells

Key Points

Discussion

Implication

Cite This Study

TIMER2.0 for analysis of tumor-infiltrating immune cells

Key Points

Discussion

Implication

Cite This Study

Also Consider

Also Consider