Why the study?
Are elevated levels of MMP-2 associated with left ventricular remodeling and poor prognosis in patients with hypertrophic cardiomyopathy?
Are elevated levels of MMP-2 associated with left ventricular remodeling and poor prognosis in patients with hypertrophic cardiomyopathy?
Elevated MMP-2 is associated with adverse LV remodeling and poor prognosis in HCM, suggesting extracellular matrix regulation as a potential therapeutic target.
Elevated MMP-2 may aid remodeling risk stratification in HCM; hypothesis-generating for matrix-targeted therapies, pending prospective trials.
Elevated levels of MMP-2 were related to LV remodeling and poor prognosis in patients with HCM. These results suggest that regulation of the extracellular collagen matrix might be one of the therapeutic targets in patients with HCM.
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Kitaoka et al. (2010) studied this question.
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